Alternative splicing regulation impacts heart development

被引：37

作者：

Cooper, TA ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

CELL | 2005年 / 120卷 / 01期

关键词：

D O I：

10.1016/j.cell.2004.12.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SR proteins serve multiple roles in the posttranscriptional control of gene expression, including as regulators of alternative splicing. In this issue of CeII, Xu et al. (2005) demonstrate that a heart-specific knockout of one SR protein, ASF/SF2, produces cardiomyopathy and misregulation of specific alternative splicing events during early postnatal development.

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页码：1 / 2

页数：2

相关论文

共 10 条

[1] Regulation of signal transduction by protein targeting: The case for CaMKII [J].

Bayer, KM ;

Schulman, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 289 (05) :917-923

[2]

Black D.L., 2003, ANNU REV BIOCHEM, V27, P27

[3] Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart [J].

Ding, JH ;

Xu, XD ;

Yang, DM ;

Chu, PH ;

Dalton, ND ;

Ye, Z ;

Yeakley, JM ;

Cheng, HP ;

Xiao, RP ;

Ross, J ;

Chen, J ;

Fu, XD .

EMBO JOURNAL, 2004, 23 (04) :885-896

[4] Sorting out the complexity of SR protein functions [J].

Graveley, BR .

RNA, 2000, 6 (09) :1197-1211

[5] Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability [J].

Jensen, KB ;

Dredge, BK ;

Stefani, G ;

Zhong, R ;

Buckanovich, RJ ;

Okano, HJ ;

Yang, YYL ;

Darnell, RB .

NEURON, 2000, 25 (02) :359-371

[6] A muscleblind knockout model for myotonic dystrophy [J].

Kanadia, RN ;

Johnstone, KA ;

Mankodi, A ;

Lungu, C ;

Thornton, CA ;

Esson, D ;

Timmers, AM ;

Hauswirth, WW ;

Swanson, MS .

SCIENCE, 2003, 302 (5652) :1978-1980

[7] Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans [J].

Lewis, BP ;

Green, RE ;

Brenner, SE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (01) :189-192

[8] Genome-wide detection of alternative splicing in expressed sequences of human genes [J].

Modrek, B ;

Resch, A ;

Grasso, C ;

Lee, C .

NUCLEIC ACIDS RESEARCH, 2001, 29 (13) :2850-2859

[9] A novel role for shuttling SR proteins in mRNA translation [J].

Sanford, JR ;

Gray, NK ;

Beckmann, K ;

Cáceres, JF .

GENES & DEVELOPMENT, 2004, 18 (07) :755-768

[10] ASF/SF2-Regulated CaMKIIδ alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle [J].

Xu, XD ;

Yang, DM ;

Ding, JH ;

Wang, W ;

Chu, PH ;

Dalton, ND ;

Wang, HY ;

Bermingham, JR ;

Ye, Z ;

Liu, F ;

Rosenfeld, MG ;

Manley, JL ;

Ross, J ;

Chen, J ;

Xiao, RP ;

Cheng, HP ;

Fu, XD .

CELL, 2005, 120 (01) :59-72