Effects of combined low-density lipoprotein apheresis and aggressive statin therapy on coronary calcified plaque as measured by computed tomography

被引：26

作者：

Hoffmann, U

Derfler, K

Haas, M

Stadler, A

Brady, TJ

Kostner, K

机构：

[1] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

[2] Univ & Gen Hosp Vienna, Dept Diagnost Radiol, Vienna, Austria

[3] Univ & Gen Hosp Vienna, Dept Nephrol, Vienna, Austria

[4] Univ & Gen Hosp Vienna, Dept Cardiol, Vienna, Austria

[5] Harvard Univ, Sch Med, Boston, MA USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 91卷 / 04期

关键词：

D O I：

10.1016/S0002-9149(02)03248-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Eight patients with heterozygous familial hypercholesterolemia who received combined long-term low-density lipoprotein apheresis and high-dose statin therapy showed a significant decrease in volume of coronary calcium over a period of 29 months as measured by, computed tomography. This suggests that the effects of aggressive lipid-lowering therapy can be assessed non-invasively and may be used as surrogate end points when testing new therapies.

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页码：461 / +

页数：5

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