α-iodocycloalkenones:: Synthesis of (±)-epibatidine

被引：48

作者：

Sirisoma, NS ^{[1
]}

Johnson, CR ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(98)00187-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of the non-opiate analgesic alkaloid epibatidine was achieved in 13 steps and 13% overall yield starting from 1,3-cyclohexadiene using in a key step a modified Stille coupling reaction on an alpha-iodocyclohexenone. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2059 / 2062

页数：4

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