Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet

被引：125

作者：

Fraser, DD

Whiting, S

Andrew, RD

Macdonald, EA

Musa-Veloso, K

Cunnane, SC

机构：

[1] Childrens Hosp Eastern Ontario, Dept Paediat, Div Crit Care Med, Ottawa, ON K1H 8L2, Canada

[2] Queens Univ, Dept Anat & Cell Biol, Kingston, ON, Canada

[3] Canadian Paediat Epilepsy Network, Clin Trials Grp, Kingston, ON, Canada

[4] Queens Univ, Dept Paediat, Kingston, ON, Canada

[5] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada

来源：

NEUROLOGY | 2003年 / 60卷 / 06期

关键词：

D O I：

10.1212/01.WNL.0000049974.74242.C6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors analyzed blood metabolites in nine children with epilepsy prior to starting the ketogenic diet (KD) and 3 to 4 weeks after KD therapy. Elevated p-hydroxybutyrate and cortisol levels were observed in all children on the KD. Free fatty acids increased 2.2-fold on the KD, with significant elevations in most polyunsaturated fatty acids (PUFA; arachidonate increased 1.6- to 2.9-fold and docosahexaenoate increased 1.5- to 4.0-fold). The rise in total serum arachidonate correlated with improved seizure control. Elevated PUFA may represent a key anticonvulsant mechanism of the KD.

引用

页码：1026 / 1029

页数：4

共 10 条

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