Diabetic Retinopathy: Animal Models, Therapies, and Perspectives

被引：75

作者：

Cai, Xue ^{[1
]}

McGinnis, James F. ^{[1
,2
,3
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK 73104 USA

[3] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Ctr Neurosci, Oklahoma City, OK 73104 USA

来源：

JOURNAL OF DIABETES RESEARCH | 2016年 / 2016卷

关键词：

MICROVASCULAR ENDOTHELIAL DYSFUNCTION; ENDOPLASMIC-RETICULUM STRESS; RETINAL BARRIER BREAKDOWN; GROWTH-FACTOR; MACULAR EDEMA; MOUSE MODEL; INTRAVITREAL INJECTION; TRANSGENIC MICE; LASER TREATMENT; EARLY-ONSET;

D O I：

10.1155/2016/3789217

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Diabetic retinopathy (DR) is one of the major complications of diabetes. Although great efforts have been made to uncover the mechanisms underlying the pathology of DR, the exact causes of DR remain largely unknown. Because of multifactor involvement in DR etiology, currently no effective therapeutic treatments for DR are available. In this paper, we review the pathology of DR, commonly used animal models, and novel therapeutic approaches. Perspectives and future directions for DR treatment are discussed.

引用

页数：9

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