Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?

被引：163

作者：

Ho, GT ^{[1
]}

Moodie, FM ^{[1
]}

Satsangi, J ^{[1
]}

机构：

[1] Western Gen Hosp, Univ Dept Med Sci, Gastrointestinal Labs, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

GUT | 2003年 / 52卷 / 05期

关键词：

D O I：

10.1136/gut.52.5.759

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The interface between luminal contents and intestinal epithelium constitutes the largest area of interaction between the host and the environment. There is now strong evidence that the gene product of the multidrug resistant pump (MDR) plays a critical role in host-bacterial interactions in the gastrointestinal tract and maintenance of intestinal homeostasis. This review highlights the efflux mechanism in the intestinal epithelium which is mediated by the multidrug resistant pump, also known as P-glycoprotein 170. Current studies promise to provide further insights into the contribution of the MDR1 gene in the pathogenesis of inflammatory and malignant disorders of the gastrointestinal tract.

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收藏

页码：759 / 766

页数：8

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