Lamotrigine treatment in childhood drug resistant epilepsy

被引：17

作者：

Buoni, S ^{[1
]}

Grosso, S ^{[1
]}

Fois, A ^{[1
]}

机构：

[1] Univ Siena, Ist Clin Pediat, I-53100 Siena, Italy

来源：

JOURNAL OF CHILD NEUROLOGY | 1998年 / 13卷 / 04期

关键词：

D O I：

10.1177/088307389801300403

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The clinical response to lamotrigine has been evaluated in a group of 63 drug resistant epileptic children in an open add-on trial. A negative response was observed in 30 subjects. In 11 patients, after an initial improvement lasting a mean period of 8 months, seizures recurred with the same frequency present before the beginning of the treatment. Twenty-two patients responded to lamotrigine treatment. Period of observation in the responsive group ranged from 1 year to 3 years. Response was complete in 16 patients and in the other 6 a 50% to 90% decrease of seizures was obtained. A complete normalization of the electroencephalogram (EEG) was registered in 10 cases after a mean period of 5 months of therapy. Side effects were mild and limited to 12 patients. Improvement was obtained in social and academic performance. Writing ability improved in one case. Lamotrigine can be considered a useful drug in the therapeutic armamentarium for childhood drug resistant epilepsy.

引用

页码：163 / 167

页数：5

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