Lamotrigine treatment in childhood drug resistant epilepsy

被引:17
作者
Buoni, S [1 ]
Grosso, S [1 ]
Fois, A [1 ]
机构
[1] Univ Siena, Ist Clin Pediat, I-53100 Siena, Italy
关键词
D O I
10.1177/088307389801300403
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The clinical response to lamotrigine has been evaluated in a group of 63 drug resistant epileptic children in an open add-on trial. A negative response was observed in 30 subjects. In 11 patients, after an initial improvement lasting a mean period of 8 months, seizures recurred with the same frequency present before the beginning of the treatment. Twenty-two patients responded to lamotrigine treatment. Period of observation in the responsive group ranged from 1 year to 3 years. Response was complete in 16 patients and in the other 6 a 50% to 90% decrease of seizures was obtained. A complete normalization of the electroencephalogram (EEG) was registered in 10 cases after a mean period of 5 months of therapy. Side effects were mild and limited to 12 patients. Improvement was obtained in social and academic performance. Writing ability improved in one case. Lamotrigine can be considered a useful drug in the therapeutic armamentarium for childhood drug resistant epilepsy.
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页码:163 / 167
页数:5
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