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Is PU.1 a dosage-sensitive regulator of haemopoietic lineage commitment and leukaemogenesis?

被引：58
作者：
Dakic, Aleksandar
Wu, Li
Nutt, Stephen L. [1 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia
来源：
TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 03期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/j.it.2007.01.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The transcription factor PU.1 is an essential regulator of haemopoiesis and a suppressor of myelloid leukaemia. PU.1 displays a complex expression pattern characterized by high expression in myelloid cells and low amounts in lymphoid cells. Based on this transcriptional profile, and the analysis of cell lines and mice expressing altered levels of PU.1, a model has been proposed where the concentration of PU.1 determines cell fate, whereas the graded reduction, but not absence, of PU.1 facilitates leukaernogenesis. The recent reports of mouse strains that enable the accurate determination of PU.1 expression and the conditional inactivation of PU.1 in adult haernopoiesis have led us to re-examine our understanding of the complexfunctions of PU.1. Here, we will discussthe data that, we believe, argue against the dosage-sensitive model of PU.1-mediated lineage commitment and leukaemogenesis.
引用
收藏
页码：108 / 114
页数：7
相关论文
共 56 条
  • [1] Upregulation of flt3 expression within the bone marrow Lin-Sca1+c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity
    Adolfsson, J
    Borge, OJ
    Bryder, D
    Theilgaard-Mönch, K
    Åstrand-Grundström, I
    Sitnicka, E
    Sasaki, Y
    Jacobsen, SEW
    [J]. IMMUNITY, 2001, 15 (04) : 659 - 669
  • [2] Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential:: A revised road map for adult blood lineage commitment
    Adolfsson, J
    Månsson, R
    Buza-Vidas, N
    Hultquist, A
    Liuba, K
    Jensen, CT
    Bryder, D
    Yang, LP
    Borge, OJ
    Thoren, LAM
    Anderson, K
    Sitnicka, E
    Sasaki, Y
    Sigvardsson, M
    Jacobsen, SEW
    [J]. CELL, 2005, 121 (02) : 295 - 306
  • [3] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    Akashi, K
    Traver, D
    Miyamoto, T
    Weissman, IL
    [J]. NATURE, 2000, 404 (6774) : 193 - 197
  • [4] Myeloid development is selectively disrupted in PU.1 null mice
    Anderson, KL
    Smith, KA
    Conners, K
    McKercher, SR
    Maki, RA
    Torbett, BE
    [J]. BLOOD, 1998, 91 (10) : 3702 - 3710
  • [5] Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage
    Anderson, MK
    Weiss, AH
    Hernandez-Hoyos, G
    Dionne, CJ
    Rothenberg, EV
    [J]. IMMUNITY, 2002, 16 (02) : 285 - 296
  • [6] Visualizing PU.1 activity during hematopoiesis
    Back, J
    Allman, D
    Chan, S
    Kastner, P
    [J]. EXPERIMENTAL HEMATOLOGY, 2005, 33 (04) : 395 - 402
  • [7] PU.1 determines the self-renewal capacity of erythroid progenitor cells
    Back, J
    Dierich, A
    Bronn, C
    Kastner, P
    Chan, S
    [J]. BLOOD, 2004, 103 (10) : 3615 - 3623
  • [8] Signal transduction of oncogenic Flt3
    Choudhary, C
    Müller-Tidow, C
    Berdel, WE
    Serve, H
    [J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2005, 82 (02) : 93 - 99
  • [9] Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells
    Christensen, JL
    Weissman, IL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) : 14541 - 14546
  • [10] PU. 1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain
    Cook, WD
    McCaw, BJ
    Herring, C
    John, DL
    Foote, SJ
    Nutt, SL
    Adams, JM
    [J]. BLOOD, 2004, 104 (12) : 3437 - 3444
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