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Is PU.1 a dosage-sensitive regulator of haemopoietic lineage commitment and leukaemogenesis?

被引：58
作者：
Dakic, Aleksandar
Wu, Li
Nutt, Stephen L. [1 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia
来源：
TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 03期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/j.it.2007.01.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The transcription factor PU.1 is an essential regulator of haemopoiesis and a suppressor of myelloid leukaemia. PU.1 displays a complex expression pattern characterized by high expression in myelloid cells and low amounts in lymphoid cells. Based on this transcriptional profile, and the analysis of cell lines and mice expressing altered levels of PU.1, a model has been proposed where the concentration of PU.1 determines cell fate, whereas the graded reduction, but not absence, of PU.1 facilitates leukaernogenesis. The recent reports of mouse strains that enable the accurate determination of PU.1 expression and the conditional inactivation of PU.1 in adult haernopoiesis have led us to re-examine our understanding of the complexfunctions of PU.1. Here, we will discussthe data that, we believe, argue against the dosage-sensitive model of PU.1-mediated lineage commitment and leukaemogenesis.
引用
收藏
页码：108 / 114
页数：7
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