Arsenic-induced skin lesions among Atacameno people in Northern Chile despite good nutrition and centuries of exposure

被引:149
作者
Smith, AH
Arroyo, AP
Mazumder, DNG
Kosnett, MJ
Hernandez, AL
Beeris, M
Smith, MM
Moore, LE
机构
[1] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA
[2] Minist Hlth, Antofagasta, Chile
[3] Postgrad Inst Med Educ & Res, Kolkata, W Bengal, India
[4] Univ Colorado, Hlth Sci Ctr, Div Clin Pharmacol & Toxicol, Denver, CO USA
[5] Cosmo Andino, San Pedro De Atacama, Chile
关键词
Chile; drinking water; nutrition; skin lesions;
D O I
10.2307/3434881
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
It has been suggested that the indigenous Aracameno people in Northern Chile might be protected from the health effects of arsenic in drinking water because of many centuries of exposure. Here we report on the first intensive investigation of arsenic-induced shin lesions in this population. We selected 11 families (44 participants) from the village of Chin Chiu, which is supplied with water containing between 750 and 800 mu g/L inorganic arsenic. For comparison, 8 families (31 participants) were also selected from a village where the water contains approximately 10 mu g/L inorganic arsenic. After being transported to the nearest city for blind assessment, participants were examined by four physicians with experience in studying arsenic-induced lesions. Four of the six men from the exposed village, who had been drinking the contaminated water for more than 20 years, were diagnosed with skin lesions due to arsenic, but none of the women had definite lesions. A 13-year-old girl had definite skin pigmentation changes due to arsenic, and a 19-year-old boy had both pigmentation changes and keratoses on the palms of his hands and the soles of his feet. Family interviews identified a wide range of fruits and vegetables consumed daily by the affected participants, as well as the weekly intake of red meat and chicken. However; the prevalence of skin lesions among men and children in the small population studied was similar to that reported with corresponding arsenic drinking water concentrations in both Taiwan and West Bengal, India-populations in which extensive malnutrition has been thought to increase susceptibility.
引用
收藏
页码:617 / 620
页数:4
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