Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm

被引：101

作者：

Markwell, Emma L.

Feigl, Beatrix

Zele, Andrew J. ^{[1
]}

机构：

[1] Queensland Univ Technol, Visual Sci & Med Retina Lab, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia

来源：

CLINICAL AND EXPERIMENTAL OPTOMETRY | 2010年 / 93卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

circadian rhythm; melanopsin; pupillary reflex; retinal disease; retinal ganglion cells; retinal photoreceptors; HYPOTHALAMIC SUPRACHIASMATIC NUCLEUS; PRIMATE RETINA; VISUAL PIGMENTS; INTERGENICULATE LEAFLET; INFRARED PUPILLOMETRY; SPECTRAL SENSITIVITY; REGULATE MELANOPSIN; COLOR-PERCEPTION; BIPOLAR CELLS; MOUSE RETINA;

D O I：

10.1111/j.1444-0938.2010.00479.x

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Recently discovered intrinsically photosensitive melanopsin retinal ganglion cells contribute to the maintenance of pupil diameter, recovery and post-illumination components of the pupillary light reflex and provide the primary environmental light input to the suprachiasmatic nucleus for photoentrainment of the circadian rhythm. This review summarises recent progress in understanding intrinsically photosensitive ganglion cell histology and physiological properties in the context of their contribution to the pupillary and circadian functions and introduces a clinical framework for using the pupillary light reflex to evaluate inner retinal (intrinsically photosensitive melanopsin ganglion cell) and outer retinal (rod and cone photoreceptor) function in the detection of retinal eye disease.

引用

页码：137 / 149

页数：13

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