Architectonics of the human cerebral cortex and transmitter receptor fingerprints: reconciling functional neuroanatomy and neurochemistry

被引:181
作者
Zilles, K
Palomero-Gallagher, N
Grefkes, C
Scheperjans, F
Boy, C
Amunts, K
Schleicher, A
机构
[1] Forschungszentrum Julich, Inst Med, D-52425 Julich, Germany
[2] Univ Dusseldorf, C&O Vogt Inst Brain Res, D-4000 Dusseldorf, Germany
关键词
human brain; cerebral cortex; neuroanatomy; neuroimaging; glutamate; GABA; acetylcholine; dopamine; noradrenaline; serotonin; adenosine;
D O I
10.1016/S0924-977X(02)00108-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The density of transmitter receptors varies between different locations in the human cerebral cortex. We hypothesized that this variation may reflect the cyto- and myeloarchitectonical as well as the functional organisation of the cortex. We compared data from different imaging modalities (postmortem studies: cyto- and myeloarchitecture, quantitative in vitro receptor autoradiography; in vivo studies: PET receptor neuroimaging) in order to test our hypothesis. The regional and laminar distribution of the densities of numerous receptor types representing all classical transmitter systems as well as the adenosine system are visualized and measured in different cortical areas. The receptor distribution patterns segregate motor, primary sensory, unimodal sensory, multimodal association and other functionally identified cortical areas from each other. Areas of similar function show similar receptor fingerprints and differ from those with other properties. Thus, receptor distribution patterns reflect an organisational structure strictly correlated with the architectonics and functions of the human cerebral cortex. (C) 2002 Elsevier Science B.V./ECNP All rights reserved.
引用
收藏
页码:587 / 599
页数:13
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