Integrin-linked kinase:: integrin's mysterious partner

被引：61

作者：

Grashoff, C ^{[1
]}

Thievessen, I ^{[1
]}

Lorenz, K ^{[1
]}

Ussar, S ^{[1
]}

Fässler, R ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Med, D-82152 Martinsried, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 05期

关键词：

D O I：

10.1016/j.ceb.2004.07.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrin-mediated cell adhesion regulates a vast number of biological processes including migration, survival and proliferation of cells. It is therefore not surprising that defects in integrin function are often rate-limiting for development and profoundly affect the progression of several diseases. The functions of integrins are mediated through the recruitment of cytoplasmic plaque proteins. One of these is integrin-linked kinase, which connects integrins to the actin cytoskeleton and transduces signals through integrins to the extracellular matrix and from integrins to various subcellular compartments.

引用

页码：565 / 571

页数：7

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