Facile, Fmoc-compatible solid-phase synthesis of peptide C-terminal thioesters

被引：84

作者：

Swinnen, D ^{[1
]}

Hilvert, D ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Organ Chem Lab, CH-8092 Zurich, Switzerland

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 16期

关键词：

D O I：

10.1021/ol0060836

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A short route to peptide C terminal thioesters was developed that does not require the use of special linkers or resins and is compatible with standard Fmoc chemistry, Following conventional solid phase peptide synthesis, an excess of Me2AlCl and EtSH in dichloromethane cleaves peptides from Wang or Pam resins to give the corresponding thioesters directly in good yield and purity.

引用

页码：2439 / 2442

页数：4

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