The adipose conversion process:: Regulation by extracellular and intracellular factors

被引:67
作者
Boone, C [1 ]
Mourot, J
Grégoire, F
Remacle, C
机构
[1] INRA, Unite Mixte Rech Veau & Porc, F-35590 St Gilles, France
[2] Parke Davis Lab Mol Genet, Alameda, CA 94505 USA
[3] Catholic Univ Louvain, Unite Biol Anim, Biol Cellulaire Lab, B-1348 Louvain, Belgium
来源
REPRODUCTION NUTRITION DEVELOPMENT | 2000年 / 40卷 / 04期
关键词
preadipocyte; differentiation; hormonal agent; second messenger; transcription factor;
D O I
10.1051/rnd:2000103
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
White adipose tissue regulates lipid metabolism and acts as a secretory organ. Because of its importance for human health and animal production, many studies have attempted to better understand its development at the cellular and molecular levels by culturing preadipose cells in vitro. This synthesis article describes our current knowledge, acquired by this approach, concerning the regulation of the different steps of the adipocyte differentiation program by extracellular (hormones, cytokines, growth factors, retinoids and fatty acids) and intracellular agents (second messengers and transcription factors). The discrepant effects that have been observed fur some of these factors are also discussed. This information is very important in the perspective of a better control of fat deposits in human and bleeding species.
引用
收藏
页码:325 / 358
页数:34
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