Alzheimer's risk associated with human apolipoprotein E, alpha-2 macroglobulin and lipoprotein receptor related protein polymorphisms:: absence of genetic interactions, and modulation by gender

被引：37

作者：

Bullido, MJ

Guallar-Castillón, P

Artiga, MJ

Ramos, MC

Sastre, I

Aldudo, J

Frank, A

Coria, F

Rodríguez-Artalejo, F

Valdivieso, F

机构：

[1] Univ Autonoma Madrid, CSIC, Dept Biol Mol, E-28049 Madrid, Spain

[2] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[3] Univ Autonoma Madrid, Fac Med, E-28029 Madrid, Spain

[4] Univ Autonoma Madrid, Hosp Univ La Paz, Serv Neurol, Madrid 28034, Spain

[5] Clin Enfermedades Sistema Nervioso, Palma de Mallorca, Spain

来源：

NEUROSCIENCE LETTERS | 2000年 / 289卷 / 03期

关键词：

apolipoprotein E; lipoprotein receptor related protein; alpha-2; macroglobulin; Alzheimer's disease; polymorphisms; gender;

D O I：

10.1016/S0304-3940(00)01304-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apolipoprotein E (apoE), the lipoprotein receptor related protein (LRP) and alpha-2 macroglobulin (alpha 2M) have been proposed as a functional complex involved in amyloid clearance, a crucial event for Alzheimer's disease development. In this work, we present an epidemiological approach aimed to study the interactions among these genes, age and gender. This approach did not reveal significant associations between the genes; however, the present study indicated that the risk associated with APOE promoter and LRP gene polymorphisms is modulated by gender. (C) 2000 Published by Elsevier Science Ireland Ltd.

引用

页码：213 / 216

页数：4

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