ApoE epsilon4 allele and disease duration affect verbal learning in mild temporal lobe epilepsy

被引:42
作者
Gambardella, T
Aguglia, U
Chifari, R
Labate, T
Manna, I
Serra, T
Romeo, T
Sibilia, G
LePiane, T
La Russa, A
Ventura, P
Cittadella, R
Sasanelli, F
Colosimo, E
Leggio, U
Zappia, M
Quattrone, T
机构
[1] Inst Neurol, Sch Med, Catanzaro, Italy
[2] CNR, Inst Neurol Sci, Cosenza, Italy
[3] Hosp Reggio Calabria, Reg Epilepsy Ctr, Reggio Di Calabria, Italy
[4] Hosp Melegnano, Neurol Clin, Milan, Italy
关键词
verbal memory; temporal lobe epilepsy; genetic predisposition; ApoE;
D O I
10.1111/j.0013-9580.2005.15804.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose: To clarify the possible role of other factors including the ApoE epsilon4 allele for memory decline in temporal lobe epilepsy (TLE). Methods: We conducted a neuropsychological and molecular study in 138 consecutive patients (78 female patients; mean age, 50.2 years, SD +/- 17.9; range, 14 to 87 years) with mild nonlesional TLE, who rarely or never had seizures at long-term follow-up. The mean age at seizure onset was 33.0 years (SD, +/- 21.7), and the mean duration of epilepsy was 17.1 years (SD, +/- 15.7). Results: Thirty-four (25 %) of 138 patients had test scores indicating verbal learning deficit (VLD). The presence of an ApoE epsilon4 allele was associated with an increased risk of VLD (OR, 4.18; 95 % CI, 1.66-10.55). The effect of the ApoE genotype was independent of both the age at epilepsy onset and disease duration as well as of a low educational level, which were separately associated with VLD (p values = 0.045, 0.001, and 0.001, respectively). A significant linear trend (p = 0.005) was seen in the relation between disease duration and cognitive impairment, with the highest risk being in patients with an epilepsy duration greater than or equal to 25.5 years (OR, 7.06; 95 % CI, 1.67-29.85), especially if they carried the 64 allele (OR, 32.29; 95 % CI, 5.23-195.72). Conclusions: These results provide evidence for an alteration in cognitive performance as a function of the presence of the ApoE epsilon4 allele and point to the critical role of disease duration itself for cognitive impairment in TLE.
引用
收藏
页码:110 / 117
页数:8
相关论文
共 58 条
[1]   Mild non-lesional temporal lobe epilepsy - A common, unrecognized disorder with onset in adulthood [J].
Aguglia, U ;
Gambardella, A ;
Le Piane, E ;
Messina, D ;
Oliveri, RL ;
Russo, C ;
Zappia, M ;
Quattrone, A .
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1998, 25 (04) :282-286
[2]   PROPOSAL FOR REVISED CLASSIFICATION OF EPILEPSIES AND EPILEPTIC SYNDROMES [J].
不详 .
EPILEPSIA, 1989, 30 (04) :389-399
[3]  
[Anonymous], 1941, L'examen clinique en psychologie
[4]   Testing for population subdivision and association in four case-control studies [J].
Ardlie, KG ;
Lunetta, KL ;
Seielstad, M .
AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (02) :304-311
[5]   Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures [J].
Bengzon, J ;
Kokaia, Z ;
Elmer, E ;
Nanobashvili, A ;
Kokaia, M ;
Lindvall, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10432-10437
[6]   Familial temporal lobe epilepsy: A common disorder identified in twins [J].
Berkovic, SF ;
McIntosh, A ;
Howell, RA ;
Mitchell, A ;
Sheffield, LJ ;
Hopper, JL .
ANNALS OF NEUROLOGY, 1996, 40 (02) :227-235
[7]   WORD FLUENCY AND BRAIN DAMAGE [J].
BORKOWSKI, JG ;
BENTON, AL ;
SPREEN, O .
NEUROPSYCHOLOGIA, 1967, 5 (02) :135-+
[8]   APOE ε4 genotype is associated with an earlier onset of chronic temporal lobe epilepsy [J].
Briellmann, RS ;
Torn-Broers, Y ;
Busuttil, BE ;
Major, BJ ;
Kalnins, RM ;
Olsen, M ;
Jackson, GD ;
Frauman, AG ;
Berkovic, SF .
NEUROLOGY, 2000, 55 (03) :435-437
[9]   Seizure-associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy - Reply [J].
Briellmann, RS ;
Syngeniotis, A ;
Berkovic, SF ;
Jackson, GD .
ANNALS OF NEUROLOGY, 2002, 52 (06) :862-862
[10]   VALIDITY OF SOME NEUROPSYCHOLOGICAL TESTS IN THE ASSESSMENT OF MENTAL DETERIORATION [J].
CALTAGIRONE, C ;
GAINOTTI, G ;
MASULLO, C ;
MICELI, G .
ACTA PSYCHIATRICA SCANDINAVICA, 1979, 60 (01) :50-56