Architecture of a microRNA-controlled gene regulatory network that diversifies neuronal cell fates

被引:49
作者
Hobert, O. [1 ]
机构
[1] Columbia Univ, Med Ctr, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA
关键词
D O I
10.1101/sqb.2006.71.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Individual cell types are defined by the expression of specific gene batteries. Regulatory networks that control cell-type-specific gene expression programs in the nervous system are only beginning to be understood. This paper summarizes a complex gene regulatory network, composed of several transcription factors and microRNAs (miRNAs), that controls neuronal subclass specification in the nervous system of the nematode Caenorhabditis elegans.
引用
收藏
页码:181 / 188
页数:8
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