Architecture of a microRNA-controlled gene regulatory network that diversifies neuronal cell fates

被引：49

作者：

Hobert, O. ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY | 2006年 / 71卷

关键词：

D O I：

10.1101/sqb.2006.71.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Individual cell types are defined by the expression of specific gene batteries. Regulatory networks that control cell-type-specific gene expression programs in the nervous system are only beginning to be understood. This paper summarizes a complex gene regulatory network, composed of several transcription factors and microRNAs (miRNAs), that controls neuronal subclass specification in the nervous system of the nematode Caenorhabditis elegans.

引用

页码：181 / 188

页数：8

共 35 条

[11] LIN-12/Notch signaling: lessons from worms and flies
Greenwald, I
[J]. GENES & DEVELOPMENT, 1998, 12 (12) : 1751 - 1762
[12] Left-right asymmetry in the nervous system:: The Caenorhabditis elegans model
Hobert, O
Johnston, RJ
Chang, S
[J]. NATURE REVIEWS NEUROSCIENCE, 2002, 3 (08) : 629 - 640
[13] Common logic of transcription factor and microRNA action
Hobert, O
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 2004, 29 (09) : 462 - 468
[14] Hobert O, 1999, DEVELOPMENT, V126, P1547
[15] Hobert O, 2006, WORM BOOK ONLINE REV
[16] Canalization of development by microRNAs
Hornstein, Eran
Shomron, Noam
[J]. NATURE GENETICS, 2006, 38 (Suppl 6) : S20 - S24
[17] A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans
Johnston, RJ
Hobert, O
[J]. NATURE, 2003, 426 (6968) : 845 - 849
[18] A novel C-elegans zinc finger transcription factor, Isy-2, required for the cell type-specific expression of the Isy-6 microRNA
Johnston, RJ
Hobert, O
[J]. DEVELOPMENT, 2005, 132 (24): : 5451 - 5460
[19] MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision
Johnston, RJ
Chang, S
Etchberger, JF
Ortiz, CO
Hobert, O
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (35) : 12449 - 12454
[20] An unusual Zn-finger/FH2 domain protein controls a left/right asymmetric neuronal fate decision in C-elegans
Johnston, Robert J., Jr.
Copeland, John W.
Fasnacht, Marc
Etchberger, John F.
Liu, Jun
Honig, Barry
Hobert, Oliver
[J]. DEVELOPMENT, 2006, 133 (17): : 3317 - 3328

← 1 2 3 4 →