Reverse vaccinology

被引：99

作者：

Mora, M ^{[1
]}

Veggi, D ^{[1
]}

Santini, L ^{[1
]}

Pizza, M ^{[1
]}

Rappuoli, R ^{[1
]}

机构：

[1] Chiron SRL, I-53100 Siena, Italy

来源：

DRUG DISCOVERY TODAY | 2003年 / 8卷 / 10期

关键词：

D O I：

10.1016/S1359-6446(03)02689-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Whole-genome sequencing of bacteria and advances in bioinformatics have revolutionized the vaccinology field, leading to the identification of potential vaccine candidates without the need for cultivating the pathogen. This approach, termed 'reverse vaccinology', reduces the time and cost required for the identification of candidate vaccines and provides new solutions for those diseases for which conventional approaches have failed. The first example of the potential of reverse vaccinology has been the identification of novel antigens of meningococcus B as potential candidates for a novel and effective vaccine. The same approach has been successfully applied to other important human pathogens, demonstrating the feasibility to develop vaccines against any infectious disease. This review focuses on some recent advances in the identification of vaccine candidates by mining the genomic sequences of pathogenic bacteria.

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页码：459 / 464

页数：6

相关论文

共 29 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[2]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[3] Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1:: In silico and in vitro screening [J].

Ariel, N ;

Zvi, A ;

Grosfeld, H ;

Gat, O ;

Inbar, Y ;

Velan, B ;

Cohen, S ;

Shafferman, A .

INFECTION AND IMMUNITY, 2002, 70 (12) :6817-6827

[4]

Bateman A, 2004, NUCLEIC ACIDS RES, V32, pD138, DOI [10.1093/nar/gkp985, 10.1093/nar/gkh121, 10.1093/nar/gkr1065]

[5] Pertussis antigens that abrogate bacterial adherence and elicit immunity [J].

Brennan, MJ ;

Shahin, RD .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 154 (04) :S145-S149

[6] Sequencing the entire genomes of free-living organisms: The foundation of pharmacology in the new millennium [J].

Broder, S ;

Venter, JC .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2000, 40 :97-132

[7] Application of genomics and proteomics for identification of bacterial gene products as potential vaccine candidates [J].

Chakravarti, DN ;

Fiske, MJ ;

Fletcher, LD ;

Zagursky, RJ .

VACCINE, 2000, 19 (06) :601-612

[8] The ProDom database of protein domain families [J].

Corpet, F ;

Gouzy, J ;

Kahn, D .

NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :323-326

[9] Recent improvements of the ProDom database of protein domain families [J].

Corpet, F ;

Gouzy, J ;

Kahn, D .

NUCLEIC ACIDS RESEARCH, 1999, 27 (01) :263-267

[10] Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus [J].

Etz, H ;

Minh, DB ;

Henics, T ;

Dryla, A ;

Winkler, B ;

Triska, C ;

Boyd, AP ;

Söllner, J ;

Schmidt, W ;

von Ahsen, U ;

Buschle, M ;

Gill, SR ;

Kolonay, J ;

Khalak, H ;

Fraser, CM ;

von Gabain, A ;

Nagy, E ;

Meinke, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (10) :6573-6578