Synthesis of 1-Substituted 2-(Trifluoromethyl)indoles via a Palladium-Catalyzed Double Amination Reaction

被引：22

作者：

Dong, Shu-Xiang ^{[1
]}

Zhang, Xing-Guo ^{[1
,2
]}

Liu, Qiong ^{[1
]}

Tang, Ri-Yuan ^{[1
]}

Zhong, Ping ^{[1
]}

Li, Jin-Heng ^{[1
,2
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China

[2] Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2010年 / 09期

基金：

中国国家自然科学基金;

关键词：

palladium; double amination; 2-chloro-1-(2-halophenyl)-3,3,3-trifluoroprop-1-enes; 2-(trifluoromethyl)indoles; N BOND FORMATION; BEARING METHOXYCARBONYL; TRIFLUOROMETHYL GROUPS; INDOLE-DERIVATIVES; INTERNAL ALKYNES; FLUORINE; ANNULATION; CHEMISTRY; ALKENYL; AMINES;

D O I：

10.1055/s-0029-1218686

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, selective protocol for the synthesis of 1-substituted 2-(trifluoromethyl)indoles has been developed by palladium-catalyzed double amination reaction of 2-chloro-1-(2-halophenyl)3,3,3-trifluoroprop-1-enes with primary amines. This route allows the formation of two C-N bonds in one pot from the reaction between 2-chloro-1-(2-halophenyl)-3,3,3-trifluoroprop-1-enes and primary amines using the Pd(2)(dba)(3)/L4/t-BuONa system.

引用

页码：1521 / 1525

页数：5

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