Azole derivatives of 1,4-benzothiazine as antifungal agents

被引：51

作者：

Fringuelli, R

Schiaffella, F

Bistoni, F

Pitzurra, L

Vecchiarelli, A

机构：

[1] Univ Perugia, Ist Chim & Tecnol Farm, I-06123 Perugia, Italy

[2] Univ Perugia, Dipartimento Med Sperimentale & Sci Biochim, I-06100 Perugia, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 01期

关键词：

1,4-benzothiazine; antifungal activity; azole antifungals;

D O I：

10.1016/S0968-0896(97)10016-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of azole derivatives of 1,4-benzothiazine 7-14 was synthesized and evaluated for the in vitro and in vivo activity against Candida albicans. Secondary alcohol 10 and its ether derivative 13 showed very good efficacy against systemic candidiasis in a murine experimental model. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：103 / 108

页数：6

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