Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1

被引：101

作者：

Lau, Wei Ling ^{[1
]}

Festing, Maria H. ^{[1
]}

Giachelli, Cecilia M. ^{[1
]}

机构：

[1] Univ Washington, Seattle, WA 98195 USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2010年 / 104卷 / 03期

关键词：

Phosphate; vascular calcification; PiT-1; kidney disease; SMOOTH-MUSCLE-CELLS; CHRONIC KIDNEY-DISEASE; APE LEUKEMIA-VIRUS; HEMODIALYSIS-PATIENTS; GROWTH-FACTOR; SERUM PHOSPHORUS; GENE-EXPRESSION; CARDIOVASCULAR-DISEASE; MATRIX MINERALIZATION; EXTRACELLULAR CALCIUM;

D O I：

10.1160/TH09-12-0814

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Elevated serum phosphate is a risk factor for vascular calcification and cardiovascular events in kidney disease as well as in the general population. Elevated phosphate levels drive vascular calcification, in part, by regulating vascular smooth muscle cell (VSMC) gene expression, function, and fate. The type Ill sodium-dependent phosphate co-transporter, PIT-1, is necessary for phosphate-induced VSMC osteochondrogenic phenotype change and calcification, and has recently been shown to have unexpected functions in cell proliferation and embryonic development.

引用

收藏

页码：464 / 470

页数：7

相关论文

共 81 条

[1]

AHLENSTIEL T, 2010, NEPHROL DIAL TRANSPL

[2] Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells [J].

Ahmed, S ;

O'Neill, KD ;

Hood, AF ;

Evan, AP ;

Moe, SM .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2001, 37 (06) :1267-1276

[3] Elastin degradation and calcification in an abdominal aorta injury model - Role of matrix metalloproteinases [J].

Basalyga, DM ;

Simionescu, DT ;

Xiong, WF ;

Baxter, T ;

Starcher, BC ;

Vyavahare, NR .

CIRCULATION, 2004, 110 (22) :3480-3487

[4] The Phosphate Transporter PiT1 (Slc20a1) Revealed As a New Essential Gene for Mouse Liver Development [J].

Beck, Laurent ;

Leroy, Christine ;

Beck-Cormier, Sarah ;

Forand, Anne ;

Salauen, Christine ;

Paris, Nadine ;

Bernier, Adeline ;

Urena-Torres, Pablo ;

Prie, Dominique ;

Ollero, Mario ;

Coulombel, Laure ;

Friedlander, Gerard .

PLOS ONE, 2010, 5 (02)

[5] Identification of a Novel Function of PiT1 Critical for Cell Proliferation and Independent of Its Phosphate Transport Activity [J].

Beck, Laurent ;

Leroy, Christine ;

Salauen, Christine ;

Margall-Ducos, Germain ;

Desdouets, Chantal ;

Friedlander, Gerard .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (45) :31363-31374

[6] Aortic pulse wave velocity index and mortality in end-stage renal disease [J].

Blacher, J ;

Safar, ME ;

Guerin, AP ;

Pannier, B ;

Marchais, SJ ;

London, GM .

KIDNEY INTERNATIONAL, 2003, 63 (05) :1852-1860

[7] Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients [J].

Block, G. A. ;

Raggi, P. ;

Bellasi, A. ;

Kooienga, L. ;

Spiegel, D. M. .

KIDNEY INTERNATIONAL, 2007, 71 (05) :438-441

[8] Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study [J].

Block, GA ;

Hulbert-Shearon, TE ;

Levin, NW ;

Port, FK .

AMERICAN JOURNAL OF KIDNEY DISEASES, 1998, 31 (04) :607-617

[9] Effects of sevelamer and calcium on coronary artery calcification in patients new to hemodialysis [J].

Block, GA ;

Spiegel, DM ;

Ehrlich, J ;

Mehta, R ;

Lindbergh, J ;

Dreisbach, A ;

Raggi, P .

KIDNEY INTERNATIONAL, 2005, 68 (04) :1815-1824

[10] Sequential activation of matrix metalloproteinase 9 and transforming growth factor β in arterial elastocalcinosis [J].

Bouvet, Celine ;

Moreau, Simon ;

Blanchette, Joannie ;

de Blois, Denis ;

Moreau, Pierre .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (05) :856-862

← 1 2 3 4 5 6 7 8 9 →