Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1

被引：101

作者：

Lau, Wei Ling ^{[1
]}

Festing, Maria H. ^{[1
]}

Giachelli, Cecilia M. ^{[1
]}

机构：

[1] Univ Washington, Seattle, WA 98195 USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2010年 / 104卷 / 03期

关键词：

Phosphate; vascular calcification; PiT-1; kidney disease; SMOOTH-MUSCLE-CELLS; CHRONIC KIDNEY-DISEASE; APE LEUKEMIA-VIRUS; HEMODIALYSIS-PATIENTS; GROWTH-FACTOR; SERUM PHOSPHORUS; GENE-EXPRESSION; CARDIOVASCULAR-DISEASE; MATRIX MINERALIZATION; EXTRACELLULAR CALCIUM;

D O I：

10.1160/TH09-12-0814

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Elevated serum phosphate is a risk factor for vascular calcification and cardiovascular events in kidney disease as well as in the general population. Elevated phosphate levels drive vascular calcification, in part, by regulating vascular smooth muscle cell (VSMC) gene expression, function, and fate. The type Ill sodium-dependent phosphate co-transporter, PIT-1, is necessary for phosphate-induced VSMC osteochondrogenic phenotype change and calcification, and has recently been shown to have unexpected functions in cell proliferation and embryonic development.

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收藏

页码：464 / 470

页数：7

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