Phenotypic variation and intracellular parasitism by Histoplasma capsulatum

被引：63

作者：

Kügler, S ^{[1
]}

Sebghati, TS ^{[1
]}

Eissenberg, LG ^{[1
]}

Goldman, WE ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 16期

基金：

英国惠康基金;

关键词：

D O I：

10.1073/pnas.97.16.8794

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The success of Histoplasma capsulatum as an intracellular pathogen depends completely on successful conversion of the saprophytic mycelial (mold) form of this fungus to a parasitic yeast form. It is therefore not surprising that yeast phase-specific genes and gene products are proving to be important for survival and proliferation of H. capsulatum within macrophages. In this study, we have focused on the role and regulation of two yeast-specific characteristics: alpha-(1,3)-glucan, a cell wall polysaccharide modulated by cell-density (quorum) sensing, and a secreted calcium-binding protein (CBP) that is essential for pathogenicity.

引用

页码：8794 / 8798

页数：5

共 18 条

[1] Calcium dependence and binding in cultures of Histoplasma capsulatum [J].

Batanghari, JW ;

Goldman, WE .

INFECTION AND IMMUNITY, 1997, 65 (12) :5257-5261

[2]

Batanghari JW, 1998, MOL MICROBIOL, V27, P531, DOI 10.1046/j.1365-2958.1998.00697.x

[3] Cell-cell communication in gram-positive bacteria [J].

Dunny, GM ;

Leonard, BAB .

ANNUAL REVIEW OF MICROBIOLOGY, 1997, 51 :527-564

[4] INFECTION OF P388D1 MACROPHAGES AND RESPIRATORY EPITHELIAL-CELLS BY HISTOPLASMA-CAPSULATUM - SELECTION OF AVIRULENT VARIANTS AND THEIR POTENTIAL ROLE IN PERSISTENT HISTOPLASMOSIS [J].

EISSENBERG, LG ;

WEST, JL ;

WOODS, JP ;

GOLDMAN, WE .

INFECTION AND IMMUNITY, 1991, 59 (05) :1639-1646

[5] HISTOPLASMA-CAPSULATUM MODULATES THE ACIDIFICATION OF PHAGOLYSOSOMES [J].

EISSENBERG, LG ;

GOLDMAN, WE ;

SCHLESINGER, PH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) :1605-1611

[6] PHAGOSOME-LYSOSOME FUSION IN P388D1 MACROPHAGES INFECTED WITH HISTOPLASMA-CAPSULATUM [J].

EISSENBERG, LG ;

SCHLESINGER, PH ;

GOLDMAN, WE .

JOURNAL OF LEUKOCYTE BIOLOGY, 1988, 43 (06) :483-491

[7] Census and consensus in bacterial ecosystems: The LuxR-LuxI family of quorum-sensing transcriptional regulators [J].

Fuqua, C ;

Winans, SC ;

Greenberg, EP .

ANNUAL REVIEW OF MICROBIOLOGY, 1996, 50 :727-751

[8]

Greenberg EP, 1997, ASM NEWS, V63, P371

[9] Codon usage limitation in the expression of HIV-1 envelope glycoprotein [J].

Haas, J ;

Park, EC ;

Seed, B .

CURRENT BIOLOGY, 1996, 6 (03) :315-324

[10] ALTERED EXPRESSION OF SURFACE ALPHA-1,3-GLUCAN IN GENETICALLY RELATED STRAINS OF BLASTOMYCES-DERMATITIDIS THAT DIFFER IN VIRULENCE [J].

HOGAN, LH ;

KLEIN, BS .

INFECTION AND IMMUNITY, 1994, 62 (08) :3543-3546

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