The power and the promise of DNA methylation markers

被引：1188

作者：

Laird, PW ^{[1
]}

机构：

[1] Univ So Calif, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 04期

关键词：

D O I：

10.1038/nrc1045

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The past few years have seen an explosion of interest in the epigenetics of cancer. This has been a consequence of both the exciting coalescence of the chromatin and DNA methylation fields, and the realization that DNA methylation changes are involved in human malignancies. The ubiquity of DNA methylation changes has opened the way to a host of innovative diagnostic and therapeutic strategies. Recent advances attest to the great promise of DNA methylation markers as powerful future tools in the clinic.

引用

页码：253 / 266

页数：14

共 172 条

[31] PURIFICATION OF CPG ISLANDS USING A METHYLATED DNA-BINDING COLUMN [J].

CROSS, SH ;

CHARLTON, JA ;

NAN, XS ;

BIRD, AP .

NATURE GENETICS, 1994, 6 (03) :236-244

[32] Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability [J].

Cui, HM ;

Horon, IL ;

Ohlsson, R ;

Hamilton, SR ;

Feinberg, AP .

NATURE MEDICINE, 1998, 4 (11) :1276-1280

[33] Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor [J].

Di Croce, L ;

Raker, VA ;

Corsaro, M ;

Fazi, F ;

Fanelli, M ;

Faretta, M ;

Fuks, F ;

Lo Coco, F ;

Kouzarides, T ;

Nervi, C ;

Minucci, S ;

Pelicci, PG .

SCIENCE, 2002, 295 (5557) :1079-1082

[34]

Domínguez G, 2002, CLIN CANCER RES, V8, P980

[35]

Eads CA, 2001, CANCER RES, V61, P3410

[36]

Eads CA, 1999, CANCER RES, V59, P2302

[37]

Eads CA, 2000, CANCER RES, V60, P5021

[38] MethyLight: a high-throughput assay to measure DNA methylation [J].

Eads, Cindy A. ;

Danenberg, Kathleen D. ;

Kawakami, Kazuyuki ;

Saltz, Leonard B. ;

Blake, Corey ;

Shibata, Darryl ;

Danenberg, Peter V. ;

Laird, Peter W. .

NUCLEIC ACIDS RESEARCH, 2000, 28 (08) :32

[39]

Esteller M, 1999, CANCER RES, V59, P67

[40] CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future [J].

Esteller, M .

ONCOGENE, 2002, 21 (35) :5427-5440

← 1 2 3 4 5 6 7 8 9 10 →