Regulation of WASP/WAVE proteins: making a long story short

被引:116
作者
Bompard, G [1 ]
Caron, E
机构
[1] Univ Birmingham, Div Mol Cell Biol, Sch Biosci, Birmingham B15 2TT, W Midlands, England
[2] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, London SW7 2AZ, England
[3] Univ London Imperial Coll Sci Technol & Med, Dept Sci Biol, London SW7 2AZ, England
基金
英国惠康基金;
关键词
D O I
10.1083/jcb.200403127
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Despite their homology, the regulation of WASP and WAVE, activators of Arp2/3-dependent actin polymerization, has always been thought to be different. Several recent studies have revealed new aspects of their regulation, highlighting its complexity and the crucial role of posttranslational modifications. New data also suggest additional functions for WASP family proteins, pushing us to reconsider existing models.
引用
收藏
页码:957 / 962
页数:6
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