Determination of enantiomeric excess of α-hydroxy-3-phenoxybenzeneacetonitrile and its n-butyl ester by chiral high-performance liquid chromatography

被引：7

作者：

Fadnavis, NW ^{[1
]}

Babu, RL

Sheelu, G

Deshpande, A

机构：

[1] Indian Inst Chem Technol, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

[2] IICT, Biochem & Environm Engn Grp, Hyderabad, Andhra Pradesh, India

来源：

JOURNAL OF CHROMATOGRAPHY A | 2000年 / 893卷 / 01期

关键词：

enantiomeric excess; alpha-hydroxy-3-phenoxybenzeneacetonitrile; cyanohydrins;

D O I：

10.1016/S0021-9673(00)00689-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Determination of enantiomeric excess of alpha-hydroxy-3-phenoxybenzeneacetonitrile, an important intermediate in the production of several pyrethroid insecticides, is usually done after derivatization and gas chromatographic analysis on a beta-cyclodextrin-based column. In this communication we report a direct determination of enantiomeric excess of alpha-hydroxy-3-phenoxybenzeneacetonitrile and its n-butyl ester by chiral HPLC on Chiralcel OJ (Daicel, Japan) in a single run without derivatization. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：189 / 193

页数：5

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