Novel consecutive β- and γ-turn mimetics composed of α-aminooxy tripeptides

被引：18

作者：

Baek, BH ^{[1
]}

Lee, MR ^{[1
]}

Kim, KY ^{[1
]}

Cho, UI ^{[1
]}

Boo, DW ^{[1
]}

Shin, I ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 07期

关键词：

D O I：

10.1021/ol020233q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] To develop novel consecutive beta- and gamma-turn mimetics, we designed and characterized alpha-aminooxy tripeptides (trimers) consisting of oxanipecotic acid dimer and alpha-aminooxy acid. According to FT-IR and NMR data, as well as ab initio quantum calculations, the trimers adopted unusual folded structures with consecutive beta- and gamma-turnlike conformations.

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收藏

页码：971 / 974

页数：4

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