Usefulness of short-term urine collection in the nutritional monitoring of low birthweight infants

被引:14
作者
Boehm, G
Wiener, M
Schmidt, C
Ungethüm, A
Ungethüm, B
Moro, G
机构
[1] Ctr Infant Nutr Prevent Illnesses Adult Life, Milan, Italy
[2] Univ Leipzig, Dept Paediat, Leipzig, Germany
关键词
creatinine; preterm infants; urine collection;
D O I
10.1080/08035259850157435
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
To establish adequacy of urine collection times shorter than 24h in the metabolic monitoring of low birthweight infants, we collected urine for 24 h in 39 LBW infants during the third and fourth week of Life. All urine voidings over the 24-h period were separately collected, the volume of each sampling and the time of voiding were recorded, and 20% of the volume was removed for pooling. All individual and pooled samples were analysed for total nitrogen, urea and ammonia, alpha-amino nitrogen, creatinine, sodium, potassium, calcium and phosphorus, and for each compound the ratio to I mol creatinine was established. Individual sample results were "pooled" to obtain 3-, 6- and 12-h period excretion and than related to the 24-h excretion as measured in the pooled 24-h sample. As the volume of urine obtained in any 6-h collecting period depended on the time of sampling (06:00-12:00 h, 17.5 +/- 3.1% of total; 12:00-18:00 h, 31.6 +/- 5.1% of total; 18:00-24:00 h, 25.6 +/- 3.1% of total; and 0:00-06:00 h, 25.3 +/- 2.9% of total), calculations were based on samples obtained from 18:00 to 06:00 h. The correlation between results of 3- and 24 h-collection periods was weakest, while results of the 6-h collection correlated highly with the total daily excretion (r = between 0.82 and 0.93 for the different compounds) and the correlation was only slightly better when the 12-h collection period was considered. The correlation between the mean molar substrate/creatinine ratio of all individual samples of a 24-h collecting period and the and total daily excretion of the respective substrate was weaker (r = between 0.46 and 0.76 for the different compounds) than the correlation between the results of a 6-h collecting period and the daily excretion is not as stable than in later life. The data indicate that 6-h urine sampling may be sufficient for metabolic monitoring of LBW infants. By contrast, urinary substrate/creatinine ratios are not good markers of the daily excretions of the respective substrate during the first weeks of life.
引用
收藏
页码:339 / 343
页数:5
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