A concise synthesis of (S)-(+)-5,6-2H-pyran-2-one via hydrozirconation-carbonylation-demetallation of O-benzyl (S)-(-)-4-pentyn-2-ol

被引：12

作者：

Dupont, J ^{[1
]}

Donato, AJ ^{[1
]}

机构：

[1] Univ Fed Rio Grande Sul, Catalysis Grp, Inst Quim, BR-91501970 Porto Alegre, RS, Brazil

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(98)00054-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A simple synthetic approach to alpha,beta-unsaturated delta-lactones has been devised from the hydrozirconation of O-protected homopropargyl alcohols followed by carbonylation and quenching with iodine. The synthesis of (S)-(+)-5,6-2H-pyran-2-one (parasorbic acid) from easily available O-benzylated (S)-(-)-4-pentyn-2-ol was chosen to exemplify the approach. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：949 / 954

页数：6

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