Circulating hepatocyte growth factor as a marker of thrombus formation in unstable angina pectoris

被引：9

作者：

Matsumori, A

Miyazaki, S

Takano, H

Ono, K

Okada, M

Miyamoto, T

Nonogi, H

Daikoku, S

Mitsudo, K

Matsunaga, Y

Ohnishi, T

Daikuhara, Y

Sasayama, S

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068397, Japan

[2] Natl Cardiovasc Ctr, Suita, Osaka 565, Japan

[3] Kurashiki Cent Hosp, Kurashiki, Okayama, Japan

[4] Kagoshima Univ, Sch Dent, Dept Biochem, Kagoshima 890, Japan

来源：

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION | 2000年 / 64卷 / 10期

关键词：

hepatocyte growth factor; thrombosis; unstable angina;

D O I：

10.1253/jcj.64.805

中图分类号：

N09 [自然科学史]; B [哲学、宗教];

学科分类号：

01 ; 0101 ; 010108 ; 060207 ; 060305 ; 0712 ;

摘要：

A new enzyme-linked immunosorbent assay can detect 10 pg/ml of human hepatocyte growth factor (HGF). Circulating HGF was significantly higher in patients with unstable angina (296+/-184 pg/ml, mean+/-SD, n=36) than in healthy volunteers (201+/-64 pg/ml, n=250, p<0.0001). Individual concentrations exceeded the mean control value +2 SD (329 pg/ml) in 12 of the 36 (33%) patients with unstable angina. The present study indicates that this new, sensitive HGF assay can successfully detect thrombosis in patients with unstable angina.

引用

页码：805 / 807

页数：3

共 10 条

[1]

BRAUNWALD E, 1994, CIRCULATION, V89, P1545

[2] UNSTABLE ANGINA - A CLASSIFICATION [J].