CD59 Blockade Enhances Antigen-Specific CD4+ T Cell Responses in Humans: A New Target for Cancer Immunotherapy?

被引：39

作者：

Sivasankar, Baalasubramanian ^{[1
]}

Longhi, M. Paula ^{[1
]}

Gallagher, Kathleen M. E. ^{[1
]}

Betts, Gareth J. ^{[1
]}

Morgan, B. Paul ^{[1
]}

Godkin, Andrew J. ^{[1
]}

Gallimore, Awen M. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Med, Dept Med Biochem & Immunol, Cardiff, S Glam, Wales

来源：

JOURNAL OF IMMUNOLOGY | 2009年 / 182卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.4049/jimmunol.0804243

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD59, a broadly expressed GPI-anchored molecule, regulates formation of the membrane attack complex of the complement cascade. We previously demonstrated that mouse CD59 also down-modulates CD4(+) T cell activity in vivo. In this study, we explored the role of CD59 on human CD4(+) T cells. Our data demonstrate that CD59 is up-regulated on activated CD4(+) 1 : cells and serves to down-modulate their activity in response to polyclonal and Ag- specific stimulation. The therapeutic potential of this finding was explored using T cells isolated from colorectal cancer patients. The findings were striking and indicated that blockade of CD59 significantly enhanced the CD4(+) T cell response to two different tumor Ags. These data highlight the potential for manipulating CD59 expression on T cells for boosting weak immune responses, such as those found in individuals with cancer. The Journal of Immunology, 2009, 182: 5203-5207.

引用

页码：5203 / 5207

页数：5

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