In vitro effects of ciprofloxacin and roxithromycin on apoptosis of Jurkat T lymphocytes

被引：40

作者：

Jun, YT

Kim, HJ

Song, MJ

Lim, JH

Lee, DG

Han, KJ

Choi, SM

Yoo, JH

Shin, WS

Choi, JH

机构：

[1] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea

[2] Catholic Univ Korea, Coll Med, Clin Res Inst, Seoul, South Korea

[3] Catholic Univ Korea, Coll Med, Dept Clin Pathol, Seoul, South Korea

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 03期

关键词：

D O I：

10.1128/AAC.47.3.1161-1164.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ciproffoxacin (CPFX) and roxithromycin (RXM) induced apoptosis of activated Jurkat T cells in vitro. CPFX showed concentration-dependent acceleration of apoptosis of activated Jurkat T cells by enhancing the expression of FasL and activities of caspase-3 and -8. RXM accelerated cell death, enhanced expression of FasL and caspase-3 but not caspase-8, and did not show the concentration dependency.

引用

页码：1161 / 1164

页数：4

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