Emerging role of microRNAs in liver diseases

被引：171

作者：

Bala, Shashi ^{[1
]}

Marcos, Miguel ^{[1
]}

Szabo, Gyongyi ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2009年 / 15卷 / 45期

关键词：

MicroRNA; Hepatitis; Fatty liver; Fibrosis; Cirrhosis; HEPATOCELLULAR-CARCINOMA; EXPRESSION PROFILES; CIRCULATING MICRORNAS; CELLULAR MICRORNAS; RNA ABUNDANCE; HEPATITIS-B; GENE; CANCER; PATHOGENESIS; METHYLATION;

D O I：

10.3748/wjg.15.5633

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

MicroRNAs are a class of small non-coding RNAs that are found in plants, animals, and some viruses. They modulate the gene function at the post-transcriptional level and act as a fine tuner of various processes, such as development, proliferation, cell signaling, and apoptosis. They are associated with different types and stages of cancer. Recent studies have shown the involvement of microRNAs in liver diseases caused by various factors, such as Hepatitis C, Hepatitis B, metabolic disorders, and by drug abuse. This review highlights the role of microRNAs in liver diseases and their potential use as therapeutic molecules. (C) 2009 The WJG Press and Baishideng. All rights reserved.

引用

页码：5633 / 5640

页数：8

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