Volume and flow dependence of respiratory mechanics in mechanically ventilated COPD patients

被引：16

作者：

Vassiliou, MP ^{[1
]}

Amygdalou, A

Psarakis, CJ

Dalavanga, Y

Vassiliou, PM

Mandragos, KE

Constantopouios, SH

Behrakis, PK

机构：

[1] Univ Ioannina, Sch Med, Dept Pneumol, GR-45110 Ioannina, Greece

[2] Univ Athens, Sch Med, Expt Physiol Lab, GR-11527 Athens, Greece

[3] Red Cross Hosp, Intens Care Unit, Athens, Greece

来源：

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2003年 / 135卷 / 01期

关键词：

disease; COPD; Mammals; human; Mechanics of breathing airway resistance; elastance; model; Model airway pressure; flow; volume; Pressure airways; Ventilation; mechanical; PEEP;

D O I：

10.1016/S1569-9048(03)00064-8

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Volume and flow dependencies of respiratory mechanics are examined in 10 COPD patients under mechanical ventilation (MV) at 3 levels of externally applied PEEP (PEEPe). Airways pressure (Paw), flow (V') and volume (V) data are analyzed according to (1) the linear and (2) a non-linear model, accounting for volume dependence of elastance and for flow and volume dependence of resistance. The models' fitness to data is assessed by the regression errors. Nonlinear modelling fits significantly better to data, while the difference of fitness decreases with PEEPe. Linear mechanics are not significantly different between the 3 levels of PEEPe. A positive volume dependence of elastance observed at 0, decreases at 5 and increases again at 10 hPa of PEEPe. A seriously negative volume dependence of resistance at 0 turned to positive with PEEPe. These dependencies of respiratory mechanics during COPD under MV, show that the present non-linear respiratory mechanical monitoring may help for better and less risky adjustment of PEEPe. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：87 / 96

页数：10