Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions?

被引：147

作者：

Davies, SW

Beardsall, K

Turmaine, M

DiFiglia, M

Aronin, N

Bates, GP

机构：

[1] UCL, Dept Anat & Dev Biol, London WC1E 6JJ, England

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, Boston, MA USA

[3] Univ Med & Dent New Jersey, Guys Hosp, Div Med & Mol Genet, London, England

来源：

LANCET | 1998年 / 351卷 / 9096期

关键词：

D O I：

10.1016/S0140-6736(97)08360-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neuronal intranuclear inclusions have been found in the brain of a transgenic mouse model of Huntington's disease and in necropsy brain tissue of patients with Huntington's disease, We suggest that neuronal intranuclear inclusions are the common neuropathology for all inherited diseases caused by expansion of polyglutamine repeats, We also suggest that patients with a pathological diagnosis of neuronal intranuclear hyaline inclusion disease may also have polyglutamine repeat expansions.

引用

页码：131 / 133

页数：3

共 39 条

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