Animal models of human disease: zebrafish swim into view

被引：1570

作者：

Lieschke, Graham J.

Currie, Peter D.

机构：

[1] Walter & Eliza Hall Inst Med Res, Canc & Haematol Div, Parkville, Vic 3050, Australia

[2] Victor Chang Cardiac Res Inst, Muscle Dev Lab, Sydney, NSW 2010, Australia

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 05期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg2091

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Despite the pre-eminence of the mouse in modelling human disease, several aspects of murine biology limit its routine use in large-scale genetic and therapeutic screening. Many researchers who are interested in an embryologically and genetically tractable disease model have now turned to zebrafish. Zebrafish biology allows ready access to all developmental stages, and the optical clarity of embryos and larvae allow real-time imaging of developing pathologies. Sophisticated mutagenesis and screening strategies on a large scale, and with an economy that is not possible in other vertebrate systems, have generated zebrafish models of a wide variety of human diseases. This Review surveys the achievements and potential of zebrafish for modelling human diseases and for drug discovery and development.

引用

页码：353 / 367

页数：15

共 126 条

[31] Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy [J].