From spindle checkpoint to cancer

被引：22

作者：

Lengauer, C ^{[1
]}

Wang, ZH ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 11期

关键词：

D O I：

10.1038/ng1104-1144

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Truncating and missense mutations in BUB1B, encoding the mitotic spindle checkpoint protein BUBR1, have been identified in individuals with mosaic variegated aneuploidy. This finding supports the idea that there is a genetic basis for aneuploidy in cancers.

引用

页码：1144 / 1145

页数：2

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