Transfer of macrophage-derived mycobacterial antigens to dendritic cells can induce naive T-cell activation

被引：14

作者：

Girvan, A ^{[1
]}

Aldwell, FE ^{[1
]}

Buchan, GS ^{[1
]}

Faulkner, L ^{[1
]}

Baird, MA ^{[1
]}

机构：

[1] Univ Otago, Dept Microbiol, Dunedin, New Zealand

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2003年 / 57卷 / 02期

关键词：

D O I：

10.1046/j.1365-3083.2003.01191.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacteria are capable of surviving and replicating in host macrophages, where they can release antigenic material into the environment. However, unlike dendritic cells (DCs), macrophages do not appear to be capable of activating naive T cells. Therefore, this work investigated antigen transfer between macrophages and DCs. We generated culture supernatants from bacille Calmette-Guerin (BCG)-infected and uninfected macrophages and then determined whether DCs could present these extracellular mycobacterial antigens to T cells. Here, we show that DCs pulsed with antigens released from BCG-infected macrophages can stimulate primed T cells in vitro and initiate naive T-cell responses in vivo . These results suggest that antigen transfer can occur between macrophages and DCs.

引用

页码：107 / 114

页数：8

共 26 条

[11] Interleukin-10 does not affect phagocytosis of particulate antigen by bonemarrow-derived dendritic cells but does impair antigen presentation [J].