Bcl-2-regulated calcium signals as common mediators of both apoptosis and autophagy

被引：42

作者：

Swerdlow, Sarah

Distelhorst, Clark W. ^{[1
]}

机构：

[1] Case Western Reserve Univ, Ctr Comprehens Canc, Dept Med, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Ctr Comprehens Canc, Dept Pharmacol, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Ctr Comprehens Canc, Dept Pathol, Cleveland, OH 44106 USA

[4] Univ Hosp Cleveland, Cleveland, OH 44106 USA

来源：

DEVELOPMENTAL CELL | 2007年 / 12卷 / 02期

关键词：

D O I：

10.1016/j.devcel.2007.01.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The calcium ion, a major intracellular second messenger, is a known mediator of apoptosis and is regulated by the antiapoptotic protein Bcl-2. A paper by Hoyer-Hansen et al. (2007) in the current issue of Molecular Cell indicates that calcium also mediates the induction of macroautophagy in a Bcl-2 regulated fashion and identifies a signaling pathway through which calcium exerts its action. These intriguing findings provoke speculation as to how a cell decides to undergo either apoptosis or macroautophagy in response to calcium signals.

引用

收藏

页码：178 / 179

页数：2

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