Expression of progesterone receptor form A and B mRNAs in uterine leiomyoma

被引：30

作者：

Fujimoto, J ^{[1
]}

Hirose, R ^{[1
]}

Ichigo, S ^{[1
]}

Sakaguchi, H ^{[1
]}

Li, YL ^{[1
]}

Tamaya, T ^{[1
]}

机构：

[1] Gifu Univ, Sch Med, Dept Obstet & Gynecol, Gifu 500, Japan

来源：

TUMOR BIOLOGY | 1998年 / 19卷 / 02期

关键词：

progesterone receptor; forms A; B; uterine leiomyoma;

D O I：

10.1159/000029983

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study was designed to determine the expression pattern of progesterone receptor form A (PR-A) and B (PR-B) mRNAs in uterine leiomyoma. Approximately equal expression of PR-A and PR-B mRNAs was designated as type AB and dominant expression of PR-B mRNA as type B. In all cases of normal uterine myometrium, PR mRNA expression was type AB. Alteration to type B in the superficial part of uterine leiomyoma was observed in approximately 40% of cases. Therefore, the relative overexpression of PR-B mRNA in the surface of uterine leiomyoma might reveal an activated phenotype of progestational proliferation, plausibly related to the growth of uterine leiomyoma.

引用

页码：126 / 131

页数：6

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