Identification and characterization of pectenotoxin (PTX) 4 and PTX7 as spiroketal stereoisomers of two previously reported pectenotoxins

被引：83

作者：

Sasaki, K

Wright, JLC

Yasumoto, T

机构：

[1] Tohoku Univ, Fac Agr, Aoba Ku, Sendai, Miyagi 981, Japan

[2] Natl Res Council Canada, Inst Mari Biosci, Halifax, NS B3H 3Z1, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 08期

关键词：

D O I：

10.1021/jo971310b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pectenotoxins (PTXs) isolated from the scallop Patinopecten yessoensis were shown to be involved in an episode of diarrhetic shellfish poisoning (DSP). A total of eight analogues (PTX1-PTX7 and PTX10) have been isolated to date, and the structures of four of these analogues (PTX1, PTX2, PTX3, and PTX6) have already been elucidated. Here, we report the characterization of PTX4 and PTX7 as 7-epi-PTX1 and 7-epi-PTX6, respectively, on the basis of NMR data and an acid-catalyzed chemical interconversion. The structures of two new artifacts, PTX8 and PTX9, produced following this treatment are also reported.

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页码：2475 / 2480

页数：6

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