ISOHOMOHALICHONDRIN-B, A NEW ANTITUMOR POLYETHER MACROLIDE FROM THE NEW-ZEALAND DEEP-WATER SPONGE LISSODENDORYX SP

被引：67

作者：

LITAUDON, M ^{[1
]}

HART, JB ^{[1
]}

BLUNT, JW ^{[1
]}

LAKE, RJ ^{[1
]}

MUNRO, MHG ^{[1
]}

机构：

[1] UNIV CANTERBURY,DEPT CHEM,CHRISTCHURCH 1,NEW ZEALAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(00)78563-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isohomohalichondrin B, a new structural type in the halichondrin group, has been isolated from the deep-water New Zealand sponge Lissodendoryx sp. Like some other members of the halichondrin family isohomohalichondrin B exhibited remarkable cytotoxicity against the P388 (murine leukaemia) cell line and selective cytotoxicity in the NCI's primary screen.

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页码：9435 / 9438

页数：4

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