Analysis and prediction of mitochondrial targeting signals

被引：46

作者：

Habib, Shukry J. ^{[1
]}

Neupert, Walter ^{[1
]}

Rapaport, Doron ^{[1
]}

机构：

[1] Univ Munich, Inst Physiol Chem, D-81377 Munich, Germany

来源：

MITOCHONDRIA, 2ND EDITION | 2007年 / 80卷

关键词：

D O I：

10.1016/S0091-679X(06)80035-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The targeting of mitochondrial precursor proteins from the cytosol to the organelle and the subsequent intramitochondrial sorting depend on specific targeting and sorting information within the precursor sequence. In the case of the cleavable presequences, the characteristics of this signal are well understood and various bioinformatics and experimental tools are available to analyze them. The challenge for the coming years is to achieve a similar level of characterization and prediction ability for the various internal targeting and sorting signals. © 2006 Elsevier Inc. All rights reserved.

引用

页码：761 / 781

页数：21

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