Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites

被引：76

作者：

Kobayashi, M ^{[1
]}

Osanai, H

Kawakami, K

Yamamoto, M

机构：

[1] Univ Tsukuba, Inst Basic Med Sci, Tsukuba, Ibaraki 3058575, Japan

[2] Jichi Med Sch, Dept Biol, Minami Kawachi, Tochigi 3290498, Japan

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 98卷 / 1-2期

关键词：

fin bud; lateral line placode; olfactory placode; otic placode; presomitic mesoderm; sine oculis; Six4; somites; tectum; zebrafish;

D O I：

10.1016/S0925-4773(00)00451-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The homeobox gene Six4/AREC3 is a member of the vertebrate Six family of transcription factor genes. In this study we describe the cloning and expression of three zebrafish homologues of Six4/AREC3, six4.1, six4.2 and six4.3. These zebrafish Six4 proteins show high homology to the mammalian Six4/AREC3 proteins in the most C-terminal region in addition to the Six domain and homeodomain. Wholemount in situ hybridization showed that six4.1 is expressed in the presumptive cranial placodal precursor cells, and later in the olfactory, otic and lateral line placodes. six4.2 is expressed in the presomitic mesoderm, somites and pectoral fin bud. six4.3 appears to be a unique member of the Six4 proteins and is expressed ubiquitously at gastrulation and later in the tectum. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：151 / 155

页数：5

共 26 条

[1]

AKIMENKO MA, 1994, J NEUROSCI, V14, P3475

[2] Cloning of the human SIX1 gene and its assignment to chromosome 14 [J].

Boucher, CA ;

Carey, N ;

Edwards, YH ;

Siciliano, MJ ;

Johnson, KJ .

GENOMICS, 1996, 33 (01) :140-142

[3] A NOVEL HOMEODOMAIN-ENCODING GENE IS ASSOCIATED WITH A LARGE CPG ISLAND INTERRUPTED BY THE MYOTONIC-DYSTROPHY UNSTABLE (CTG)(N) REPEAT [J].

BOUCHER, CA ;

KING, SK ;

CAREY, N ;

KRAHE, R ;

WINCHESTER, CL ;

RAHMAN, S ;

CREAVIN, T ;

MEGHJI, P ;

BAILEY, MES ;

CHARTIER, FL ;

BROWN, SD ;

SICILIANO, MJ ;

JOHNSON, KJ .

HUMAN MOLECULAR GENETICS, 1995, 4 (10) :1919-1925

[4] cSix4, a member of the six gene family of transcription factors, is expressed during placode and somite development [J].

Esteve, P ;

Bovolenta, P .

MECHANISMS OF DEVELOPMENT, 1999, 85 (1-2) :161-165

[5]

Haddon C, 1996, J COMP NEUROL, V365, P113, DOI 10.1002/(SICI)1096-9861(19960129)365:1<113::AID-CNE9>3.0.CO

[6]

2-6

[7] Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development [J].

Kawakami, K ;

Ohto, H ;

Ikeda, K ;

Roeder, RG .

NUCLEIC ACIDS RESEARCH, 1996, 24 (02) :303-310

[8] Identification and expression of six family genes in mouse retina [J].

Kawakami, K ;

Ohto, H ;

Takizawa, T ;

Saito, T .

FEBS LETTERS, 1996, 393 (2-3) :259-263

[9]

Kobayashi M, 1998, DEVELOPMENT, V125, P2973

[10]

Metcalfe W.K., 1989, P147

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