Enzymatic fucosylations of non-natural sialylated type-I trisaccharides with recombinant fucosyl-transferase-III

被引：15

作者：

Baisch, G ^{[1
]}

Öhrlein, R ^{[1
]}

Streiff, M ^{[1
]}

机构：

[1] NOVARTIS PHARMA AG, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(97)10202-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Recombinant fucosyl-transferase-III (Lewis type enzyme) is used to prepare a series of non-natural sialyl-Lewis(a) derivatives on a preparative scale. The enzyme tolerates a wide range of accepters which have the natural N-acetyl group of the glucosamine moiety replaced by substituted aromatic and heteroaromatic amides. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：161 / 164

页数：4

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