Messenger RNA turnover in eukaryotes: Pathways and enzymes

被引：285

作者：

Meyer, S ^{[1
]}

Temme, C ^{[1
]}

Wahle, E ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Inst Biochem, D-06120 Halle An Der Saale, Germany

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2004年 / 39卷 / 04期

关键词：

mRNA decay; cap; poly(A) tail; regulation of gene expression;

D O I：

10.1080/10409230490513991

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The control of mRNA degradation is an important component of the regulation of gene expression since the steady-state concentration of mRNA is determined both by the rates of synthesis and of decay. Two general pathways of mRNA decay have been described in eukaryotes. Both pathways share the exonucleolytic removal of the poly(A) tail (deadenylation) as the first step. In one pathway, deadenylation is followed by the hydrolysis of the cap and processive degradation of the mRNA body by a 5' exonuclease. In the second pathway, the mRNA body is degraded by a complex of 3' exonucleases before the remaining cap structure is hydrolyzed. This review discusses the proteins involved in the catalysis and control of both decay pathways.

引用

页码：197 / 216

页数：20

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