Protein folding on the ribosome

被引：103

作者：

Cabrita, Lisa D. ^{[1
,2
,3
]}

Dobson, Christopher M. ^{[1
]}

Christodoulou, John ^{[2
,3
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] UCL, Inst Struct & Mol Biol, London, England

[3] UCL, Birkbeck Coll, London, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2010年 / 20卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

SIGNAL-RECOGNITION PARTICLE; NASCENT POLYPEPTIDE-CHAIN; 2-DIMENSIONAL NMR-SPECTROSCOPY; CELL-FREE TRANSLATION; PEPTIDYL-TRANSFER-RNA; TRIGGER FACTOR; ESCHERICHIA-COLI; MESSENGER-RNA; IN-VITRO; CONDUCTING CHANNEL;

D O I：

10.1016/j.sbi.2010.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In living systems, polypeptide chains are synthesised on ribosomes, molecular machines composed of over 50 protein and nucleic acid molecules. As nascent chains emerge from the ribosomal exit tunnel and into the cellular environment, the majority must fold into specific structures in order to function. In this article we discuss recent approaches designed to reveal how such folding occurs and review our current knowledge of this complex self-assembly process.

引用

页码：33 / 45

页数：13

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