Expression analysis and chromosomal mapping of a novel human gene, APRIL, encoding an acidic protein rich in leucines

被引：35

作者：

Mencinger, M ^{[1
]}

Panagopoulos, I

Contreras, JA

Mitelman, F

Åman, P

机构：

[1] Univ Lund Hosp, Dept Clin Genet, S-22185 Lund, Sweden

[2] Lund Univ, Dept Cell & Mol Biol, S-22100 Lund, Sweden

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1395卷 / 02期

关键词：

APRIL gene; APRIL protein; gene expression; chromosomal localization; EST database; leucine-rich repeat;

D O I：

10.1016/S0167-4781(97)00165-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Clone 120041 was selected from the EST database for sequence similarity to DEK and SET proteins rearranged in leukemias. The ends of the cDNA were isolated by RACE technique, The assembled cDNA encodes an LRR-containing protein of 251 aminoacids designated APRIL (acidic protein rich in leucines). APRIL has high similarity to human pp32, also named PHAPI (bovine I-1(PP2A)), and to rat LANP, respectively. APRIL shows tissue-specific expression as shown by Northern blot analysis. II was localized to 15q25 by FISH. (C) 1998 Elsevier Science B.V.

引用

页码：176 / 180

页数：5

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